glp-1 controversy The 'GLP-1 eats your muscle' alarm is everywhere right now. Here is what the actual data shows — and why an obesity medicine physician called it a manufactured controversy. The nuance: lean Use of GLP - 1

15 In the first case, a longitudinal assessment demonstrates clear worsening in symptoms with taper or discontinuation of tirzepatide and clear improvement in symptoms with initiation or titration of tirzepatide

Lancet 392 (10160), 21802193

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However, the observed phenotype in these mice was again not a simple ramification of mucosal barrier deregulation, but was the result of a conglomerate of defects in epithelial homeostasis, including epithelial cell apoptosis and barrier function irregularities